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病原生物研究所

  • 姓 名:

    葛纪弯

  • 单 位:

    中国医学科学院病原生物学研究所

  • 教职岗位:

    助理教授

  • 聘任时间:

    2023-03-06

  • 一级学科:

    生物学

  • 二级学科:

    生物化学与分子生物学

  • 联系方式:

    gjwsdu@163.com

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2023200181

个人简介

葛纪弯,副研究员,博士研究生导师。主持国家自然科学基金青年项目、中国博士后科学基金面上项目等2项,入选2025年北京市高创计划青年人才托举工程,2023年科睿唯安“中国高被引学者”,2020年中国医学科学院重要医学进展,被评为清华大学优秀博士后等。 院校引进人才,2023年加入院校。2019年10月-2023年02月 清华大学大学生命科学学院,博士后。


主要研究内容

探究重要病原与宿主相互作用的结构机理与分子机制。聚焦重要新发再发传染病,包括冠状病毒、猴痘病毒、流感病毒和RSV等,解析其分子入侵机制以及中和抗体的保护机制,为发展新型抗病毒药物提供理论指导。近五年,以(共同)第一作者/通讯作者身份发表SCI论文14篇,包括Nature(2篇),Immunity,Nature Communications(3篇),Structure(2篇),Cell Research,Cell Discovery,NPJ Vaccines等,累计被引超4800次。


代表性成果

1. Qu, Y.#, Tai, W.#, Ma, E.#, Jiang, Q.#, Fan, M., Xiao, W., Tian, C., Liu, Y., Liu, J., Wang, X., Ge, J.*, Cheng, G.* (2025). Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus. Nature Communications 16 (1):3100.

2. Lv, K.#, Li, X.#, Zhu, X.#, Cai, J.-P.#, Liu, S.#, Sun, Y., Liu, L., Cai, X., Cao, R., Xu, M., Yue, X., Zhai, Y., Luo, W., Lu, H., Li, R., Mai, H., Deng, L., Ye, F., Chen, S., Shi, M., Luo, H., Wang, X., Yuan, S.*, Shu, Y.*, Ge, J.*, Chen, Y.-Q.* (2025). Broad neuraminidase antibodies confer protection against seasonal and avian influenza viruses. Nature Communications 16 (1):7103.

3. Yang, X.#, Guo, L.#, Duan, H.#, Fan, M.#, Xu, F., Chi, X., Pan, S., Liu, X., Zhang, X., Gao, P., Zhang, F., Wang, X., Guo, F., Ge, J.*, Ren, L.*, Yang, W.* (2025). Identification of neutralizing nanobodies protecting against poxvirus infection. Cell Discovery 10 (1):771.

4.  Lan, J.#, Chen, P.#, Ren, W., Zhang, L., Ding, Q., Zhang, Q.*, Wang, X.*, Ge, J.* (2022). Structural insights into the binding of SARS-CoV-2, SARS-CoV and hCoV-NL63 spike receptor-binding domain to horse ACE2. Structure 30(10):1432-1442.

5. Lan, J.#, He, X.#, Ren, Y.#, Wang, Z.#, Zhou, H., Fan, S., Zhu, C., Liu, D., Shao, B., Liu, T.-Y., Wang, Q., Zhang, L.*, Ge, J.*, Wang, T.*, Wang, X.* (2022). Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction. Cell Research (2022) 32 (6):593–595.

6. Ge, J.#, Wang, R.#, Ju, B.#, Zhang, Q.#, Tian, Y., Shan, S., Cheng, L., Zhou, B., Song, S., Zhao, J., Wang, H., Shi, X., Ding, Q., Liu, L., Sun, J., Zhao, J., Zhang, S., Zhang, Z.*, Wang, X.*, Zhang, L.* (2021). Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications 12 (1):250.

7. Wang, R.#, Zhang, Q.#, Ge, J.#, Ren, W., Zhang, R., Lan, J., Ju, B., Su, B., Yu, F., Chen, P., Liao, H., Feng, Y., Li, X., Shi, X., Zhang, Z., Zhang, F., Ding, Q., Zhang, T.*, Wang, X.*, Zhang, L*. (2021). Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species. Immunity 54, 1611-1621.

8. Lan, J.#, Ge, J.#, Yu, J.#, Shan, S.#, Zhou, H., Fan, S., Zhang, Q., Shi, X., Wang, Q., Zhang, L.*, Wang, X*. (2020). Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 581, 215-220. (ESI).

9. Ju, B.#, Zhang, Q.#, Ge, J.#, Wang, R., Sun, J., Ge, X., Yu, J., Shan, S., Zhou, B., Song, S., Tang, X., Yu, J., Lan, J., Yuan, J., Wang, H., Zhao, J., Zhang, S., Wang, Y., Shi, X., Liu, L., Zhao, J., Wang, X. *, Zhang, Z. *, Zhang, L.* (2020). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 584 (7821):115–119. (ESI).

10. Ge, J.#, Remesh, S.G.#, Hammel, M., Pan, S., Mahan, A.D., Wang, S.*, Wang, X.* (2019). Functional Relevance of IL-1 Receptor Inter-domain Flexibility for Cytokine Binding and Signaling. Structure 27 (8):1296–1307.