冷泠，研究员，博士生导师，转化医学国家重大科技基础设施独立PI，疑难、重症及罕见病全国重点实验室独立PI。作为第一完成人，曾获日内瓦国际发明展金奖、北京市科学技术奖-杰出青年中关村奖、中国发明协会发明创业奖人物奖和创新创业二等奖等。入选2023年度“长江学者奖励计划”青年学者国家高层次人才计划。获得国家自然科学基金、国家重点研发计划、北京市科技计划、军委重点研发专项、中央高水平医院临床研究重点项目等资助。院校引进人才。

长期从事复杂类器官构建与疾病应用的研究。创建空间基质组学技术，揭示ECM调控干细胞命运和类器官重建；创建多种近似生理组织的类器官模型及其在疾病机制、组织修复和药物研发应用的技术体系，提供疑难重症罕见性重大疾病干预策略。以通讯作者身份在Nature子刊、Cell子刊等发表多篇研究性论著，8篇受邀杂志封面、F1000Prime亮点推荐等。培养本硕博和博后40余名，多人在NEJM等发表文章，获国家奖学金和国家级课题。

1. Ying Wang#, Yujie Wang#, Yao Yang, Ling Leng*. Prodrug nanosystem equipped with a sonosensitizer for combined chemotherapy and sonodynamic therapy of melanoma. Mater Today Bio, 2025, Aug 30:34:102262. (IF=10.2, F1000)

2. Jun Li#, Jie Ma#, Ruiyuan Cao#, Qiyu Zhang#, Mansheng Li#, Wenwen Wang, Yujie Wang, Wei Li, Yunping Zhu, Ling Leng*. A skin organoid-based infection platform identifies an inhibitor specific for HFMD. Nat Commun. 2025, Mar 13;16(1):2513. (IF=15.7)

3. Qiyu Zhang#, Jie Ma#, Jia Zhou#, Hanlin Zhang#, Mansheng Li#, Huizi Gong, Yujie Wang, Heyi Zheng, Jun Li*, Ling Leng*. A Study on the Inflammatory Response of the Brain in Neurosyphilis. Adv Sci. 2024, Nov 22;12(5):2406971 (IF=14.1)

4. Wenwen Wang#, Pu Liu#, Wendi Zhu#, Tianwei Li, Ying Wang, Yujie Wang, Jun Li, Jie Ma*, Ling Leng*. Skin organoid transplantation promotes tissue repair with scarless in frostbite. Protein Cell, 2024, Oct 4:pwae055 (IF=12.8)

5. Wendi Zhu#, Yue Wu#, Xiao Li#, Hongjun Yang, Fuchu He, Jie Ma*, Junying Wei*, Ling Leng*. A stroke organoids-multiomics platform to study injury mechanism and drug response. Bioact Mater, 2024, Feb Volume 44, Pages 68-81 (IF=20.3)

6. Jun Li#*, Jie Ma#, MingJuan Liu#, Mansheng Li#, Ming Zhang#, Wenhao Yin#, Mengyin Wu#, Xiao Li, Qiyu Zhang, Hanlin Zhang, Heyi Zheng, Chenhui Mao, Jian Sun, Wenze Wang, Wei Lyu, Xueping Yue, Wenjia Weng, Juan Li, Fengxin Chen, Yunping Zhu*, Ling Leng*. Large-Scale Proteome Profiling Identifies Biomarkers Associated with Suspected Neurosyphilis Diagnosis. Adv Sci. 2024, Feb 21:e2307744. (IF=15.1)

7. Jun Li#*, Jie Ma#, Qiyu Zhang#, Huizi Gong, Dunqin Gao, Yujie Wang, Biyou Li, Heyi Zheng, Zhihong Wu, Yunping Zhu*, Ling Leng*. Spatially proteomic map shows that extracellular matrix regulates epidermal growth. Nat Commun. 2022, Jul 11;13(1):4012. (IF=17.7, F1000)

8. Ling Leng#*, Jie Ma#, PeiPei Zhang#, SiChi Xu#, Xiao Li#, Ye Jin#, Jun Cai, Rui Tang, Lei Zhao, ZhiCheng He, ManSheng Li, Hui Zhang, LiangRui Zhou, ZhiHong Wu, TianRan Li, YunPing Zhu, HaiBo Wu, YiFang Ping, XiaoHong Yao, ChuHong Zhu, HaiTao Guo, LeYong Tan, ZhiYong Liang*, XiuWu Bian*, ShuYang Zhang*. Spatial-region-resolved proteome map reveals mechanism of COVID-19-associated heart injury. Cell Reports. 2022, Jun 14;39(11):110955. (IF=10.0)

9. Jie Ma#, Wei Li#, Ruiyuan Cao#, Dunqin Gao#, Qiyu Zhang, Xiao Li, Biyou Liu, Luye Lv, Mansheng Li, Junyi Jiang, Yujie Wang, Zhihong Wu, Jun Li, Yunping Zhu, Wu zhong*, Shuyang Zhang*, Ling leng*. Application of an iPSC-derived organoid model for located scleroderma therapy. Adv Sci. 2022, May;9(16):e2106075. (IF=17.5)

10. Jie Ma#, Jia liu#, Dunqin Gao#, Xiao Li#, Qiyu Zhang, Luye Lv, Yujie Wang, Jun Li, Yunping Zhu, Zhihong Wu, Hengrui Hu, Yufeng Li, Longda Ma, Qian Liu, Zhihong Hu, Shuyang Zhang*, Yiwu Zhou*, Manli Wang*, Ling Leng*. Establishment of human pluripotent stem cell-derived skin organoids enabled pathophysiological model of SARS-CoV-2 infection, Adv Sci. 2021, Dec 31;e2104192. (IF=17.5)