文礼，研究员，博士生导师。曾获上海市青年拔尖人才、青年东方学者和浦江人才等人才称号，曾获“十大医学新锐”，曾获美国胃肠病学会、美国胰腺病学会青年学者奖。获得国家自然科学基金优秀青年科学基金（青B）等项目资助。
     院校引进人才，2022年加入院校。曾于2015-2018年在美国匹兹堡大学医学院进行博士后训练。2019年1月加入上海交通大学附属第一人民医院任独立PI并先后聘为副研究员和研究员（2021年，破格）。2022年9月入职北京协和医院。

本课题组长期致力于胰腺炎相关研究，聚焦于发病机制解析与早期干预靶点探索、胰腺损伤后修复机制、纤维化及炎-癌转化过程中的免疫调控，以及高脂血症型胰腺炎重症化与复发的临床与基础研究。以通讯或第一作者（含共同）在领域内权威期刊发表论文30余篇，包括Gastroenterology、American Journal of Gastroenterology、Cell Communication and Signaling、Function(Oxf)、JCI insight、British Journal of Pharmacology、Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease等国际知名期刊。

1. Bin Li#, Xiuli Zhang#, Song Liu, Xiaoyu Guo, Wanyi Lu, Kaixin Peng, Liu R, Zhigao Chen, Liang Li, Guoyong Hu, Sohail Z. Husain, Xingpeng Wang*, Li Wen*（最后通讯作者）. AXL and MERTK facilitate tissue repair in severe acute pancreatitis via a CCR5-dependent neutrophil and macrophage crosstalk. Cell Communication and Signaling. 23, 388 (2025). (IF=8.9)

2. Hanzhang Deng#, Kaixin Peng#, Liang Zhang, Jiongdi Lu, Wentong Mei, Xiaolei Shi, Yunpeng Peng, Kedong Xu, Haoxuan Li, Zheng Wang, Lu G, Wang G, Guotao, Lu, Feng Cao*, Li Wen*（最后通讯作者）. Clinical Outcomes in A Multi-Center Cohort Involving 919 Patients with Hypertriglyceridemia-associated Acute Pancreatitis. The American Journal of Gastroenterology 120(10):p 2405-2414 (IF=7.6)

3. Mengya Niu#, Xiuli Zhang#, Zengkai Wu, Bin Li, Jingpiao Bao, Juanjuan Dai, Zihan Yang, Yue Zeng, Liang Li, Stephen Pandol, Robert Sutton, Li Wen（独立通讯作者）. Neutrophil-specific orai1 calcium channel inhibition reduces pancreatitis-associated acute lung injury. Function (Oxf) 2024;5(1): zqad061. doi: 10.1093/function/zqad061. (IF=6.2)

4. Mengya Niu, Xiuli Zhang, Pengli Song, Liang Li, Li Wen（独立通讯作者）. Intraductal pressure in experimental models of acute and chronic pancreatitis in mice. Pancreatology 2022; 22(7):917-924.(IF=3.6)

5. Jingpiao Bao#, Xiuli Zhang#, Bin Li, Mengya Niu, Zengkai Wu, Pengli Song, Xiaoyu Guo, Liang Li, Guoyong Hu*, Li Wen*（最后通讯作者）. AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via selectively limiting CXCL2-related neutrophil infiltration. BBA -Molecular Basis of Disease 1868(12):166490. (IF=6.2)

6. Juanjuan Dai#, Mingjie Jiang#, Yangyang Hu#, Jingbo Xiao, Bin Hu, Jiyao Xu, Xiao Han, Shuangjun Shen, Bin Li, Zengkai Wu, Yan He, Yingchun Ren, Li Wen*（共同通讯作者）, Xingpeng Wang*, Guoyong Hu*. Dysregulated SREBP1c/miR-153 signaling induced by hypertriglyceridemia worsens acute pancreatitis and delays tissue repair. JCI Insight. 2021; 6(2). (IF=9.484)

7. Xiao Han#, Jianbo Ni#, Zengkai Wu#, Jianghong Wu, Bin Li, Xin Ye, Juanjuang Dai, Congying Chen, Jing Xue, Rong Wan, Li Wen*（共同通讯作者）, Xingpeng Wang*, Guoyong Hu*. Myeloid-specific dopamine D2 receptor signaling controls inflammation in acute pancreatitis via inhibiting M1 macrophage. British Journal of Pharmacology. 2020; 177 (13): 2991-3008. (IF=8.739)

8. Li Wen*（第一兼共同通讯作者）, Javed TA, Dobbs AK, Brown R, Niu M, Li L, Khalid A, Barakat M, Xiao X, Yimlamai D, Konnikova L, Yu M, Byersdorfer CA, Husain SZ*. The Protective Effects of Calcineurin on Pancreatitis in Mice Depend on Cellular Source. Gastroenterology 2020; 159 (3): 1036-1050. (IF=22.682)

9. Li Wen#（共同第一作者）, Tanveer A. Javed#, Dean Yimlamai, Amitava Mukherjee, Xiangwei Xiao, and Sohail Z. Husain. Transient high pressure in pancreatic ducts promotes inflammation and alters tight junctions via calcineurin signalling. Gastroenterology 2018; 155 (4):1250-1263.e5. (IF=19.233)

10. Li Wen（独立第一作者）, Svetlana Voronina, Muhammad A Javed, Muhammad Awais, Peter Szatmary, Diane Latawiec, Michael Chvanov, David Collier, Wei Huang, John Barrett, Malcolm Begg, Ken Stauderman, Jack Roos, Sergey Grigoryev, Evan Roger, Jeffrey Whitten, Gonul Velicelibi, Michael Dunn, Alexei Tepikin, David. N. Criddle and Robert Sutton*. Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models. Gastroenterology 2015; 149 (2): 481-92. (IF=18.187, F1000)