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血液病医院

  • 姓 名:

    韦俊

  • 单 位:

    中国医学科学院血液病医院(中国医学科学院血液学研究所)

  • 教职岗位:

    助理教授

  • 聘任时间:

    2021-2-26

  • 一级学科:

    临床医学

  • 二级学科:

    干细胞与再生医学

  • 联系方式:

    weijun@ihcams.ac.cn

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2021140004

个人简介

韦俊,研究员,博士生导师。2008年本科毕业于南开大学生命科学学院。2013年于南开大学生命科学学院毕业,获生物化学与分子生物学博士学位。获得国家自然科学基金A+B专项项目及国家海外引进青年人才项目资助。 院校引进人才,2021年加入院校,曾在美国St. Jude Children’s Research Hospital免疫系从事博士后研究。


主要研究内容

主要研究方向为解析生理及病理状态下免疫细胞功能分化的分子调控网络及干预策略,探究免疫耐受和免疫应答建立和重构的新机制与新策略。研究成果在Nature,Nature Immunology,Nature Communications,Biomaterials等杂志上发表。


代表性成果

1. Gao Y, Chi Y, Chen Y, Wang W, Li H, Zheng W, Zhu P, An J, Duan Y, Sun T, Liu X, Xue F, Liu W, Fu R, Han Z, Zhang Y, Yang R, Cheng T, Wei J*, Zhang L*, Zhang X*. (2023) Multi-omics analysis of human mesenchymal stem cells shows cell aging that alters immunomodulatory activity through the downregulation of PD-L1. Nature Communications, 4373(14)

2. Long L#, Wei J#, Lim SA, Raynor J, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NW, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang Y-D, Li Y, Niu M, Dhungana Y, KC A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H. (2021) CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Nature, 600(7888):308-313

3. Lim SA#, Wei J#, Nguyen TM, Shi H, Su W, Palacios G, Dhungana Y, Chapman NM, Long L, Saravia J, Vogel P, Chi H. (2021) Lipid signalling enforces functional specialization of Treg cells in tumours. Nature, 591(7849):306-311 (Selected by News and Views, Nature, 591(7849):204-206, 2021; F1000 recommended article)

4. Wei J#, Long L#, Zheng W, Dhungana Y, Lim S, Guy C, Wang Y, Wang Y-D, Qian C, Xu B, KC A, Saravia J, Huang H, Yu J, Doench JG, Geiger TL, Chi H. (2019) Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature, 576(7787):471-476 (Selected by News and Views, Nature, 576(7787):392-393, 2019; Selected by Research Highlights, Nature Reviews Drug Discovery, 19:91, 2020; Selected by Research Highlight, Nature Immunology, 21:103, 2020; F1000 recommended article)

5. Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, Wu C, Vogel P, Neale G, Green DR, Chi H. (2016) Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nature Immunology, 17(3):277-85. (Cover Story; Selected by Research Highlights, Nature Reviews Immunology, 16(4):203, 2016)

6. Wei J#, Yang K#, Chi H. (2014) Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision. The Journal of Immunology, 193(9):4297-4301.

7. Xia S#, Wei J#, Wang J, Sun H, Zheng W, Li Y, Sun Y, Zhao H, Zhang S, Wen T, Zhou X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z. (2014) A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. Journal of Leukocyte Biology, 95(5):733-742.

8. Wei J#, Xia S#, Sun H, Zhang S, Wang J, Zhao H, Wu X, Chen X, Hao J, Zhou X, Zhu Z, Gao X, Gao JX, Wang P, Wu Z, Zhao L, Yin Z. (2013) Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells. The Journal of Immunology, 191(1):500-8.

9. Wei J#, Wang H#, Zhu M, Ding D, Li D, Yin Z, Wang L, Yang Z. (2013) Janus nanogels of PEGylated Taxol and PLGA-PEG-PLGA copolymer for cancer therapy. Nanoscale, 5(20):9902-7.

10. Wang H#, Wei J#, Yang C, Zhao H, Li D, Yin Z, Yang Z. (2012) The inhibition of tumor growth and metastasis by self-assembled nanofibers of taxol. Biomaterials, 33(24):5848-53.