原佳沛，研究员，博士生导师，北京协和医学院准聘助理教授，天津市生物医学工程学会精准医学技术专业委员会常务委员。 院校引进人才，2021年加入院校。本科毕业于山东大学，博士毕业于清华大学，生物信息学方向。后在美国UTSouthwestern Medical Center进行博士后研究（2017年10月至2020年12月）。

以“三维基因组学与肿瘤精准诊疗”为核心方向，开展系统性研究。相关成果以第一作者/通讯作者（含共同）在Cancer Discovery (2022)，Nature Communications (2024a, 2024b), Genome Medicine (2024), Cancer Letters (2024)，Journal of Clinical Investigation (2020) 等权威期刊，总引用次数1400余次，H指数12，ESI高被引论文2篇。开发的研究方法获得国家发明专利1项，累计承担多项国家及院校级科研课题。

1. Jiapei Yuan^{#, *}, Yang Tong^#, Le Wang, Xiaoxiao Yang, Xiaochuan Liu, Meng Shu, Zekun Li, Wen Jin, Chenchen Guan, Yuting Wang, Qiang Zhang^*, Yang Yang^*. A compendium of genetic variations associated with promoter usage across 49 human tissues. Nature Communications. 2024 Oct 9;15(1):8758. (IF=15.7)

2. Jiapei Yuan^#*, Jingliao Zhang^#, Beibei Zhao, Fang Liu, Tianfeng Liu, Yongjuan Duan, Yumei Chen, Xiaojuan Chen, Yao Zou, Li Zhang, Ye Guo, Wenyu Yang, Yang Yang, Jun Wei^*, Xiaofan Zhu^*, Yingchi Zhang^*. Single-cell transcriptomic analysis of the immune microenvironment in pediatric acute leukemia. Cancer Letters. 2024 Jun 4:217018. (IF=10.1)

3. Xiaochuan Liu^#, Hao Chen^#, Zekun Li, Xiaoxiao Yang, Wen Jin, Yuting Wang, Jian Zheng, Long Li, Chenghao Xuan, Jiapei Yuan*, Yang Yang*. InPACT: a computational method for accurate characterization of intronic polyadenylation from RNA sequencing data. Nature Communications. 2024 Mar 22;15(1):2583. (IF=15.7)

4. Zekun Li^#, Gerui Liu^#, XiaoXiao Yang^#, Meng Shu, Wen Jin, Yang Tong, Xiaochuan Liu, Yuting Wang, Jiapei Yuan*, Yang Yang*. An atlas of cell-type-specific interactome networks across 44 human tumor types. Genome Medicine, 2024 Feb 12;16(1):30. (IF=11.2).

5. Jiapei Yuan^#, Yang Tong^#, Xiaochuan Liu, Mulin Jun Li, Qiang Zhang^*, Yang Yang^*. eaQTLdb: An atlas of enhancer activity quantitative trait loci across cancer types. International Journal of Cancer, 2023 Jul 1;153(1):111-119. (IF=5.7).

6. Jiapei Yuan, Kathleen E Houlahan, Susmita G Ramanand, Sora Lee, GuemHee Baek, Yang Yang, Yong Chen, Douglas W Strand, Michael Q Zhang, Paul C Boutros, Ram S Mani^*. Prostate cancer transcriptomic regulation by the interplay of germline risk alleles, somatic mutations and 3D-genomic architecture. Cancer Discovery, 2022, Dec 2;12(12):2838-2855. (IF=29.1)

7. Susmita G Ramanand^#, Yong Chen^#, Jiapei Yuan^#, Kelly Daescu, Maryou Bk Lambros, Kathleen E Houlahan, Suzanne Carreira, Wei Yuan, GuemHee Baek, Adam Sharp, Alec Paschalis, Mohammed Kanchwala, Yunpeng Gao, Adam Aslam, Nida Safdar, Xiaowei Zhan, Ganesh V Raj, Chao Xing, Paul C Boutros, Johann de Bono, Michael Q Zhang^*, Ram S Mani^*. The Landscape of RNA Polymerase II Associated Chromatin Interactions in Prostate Cancer. Journal of Clinical investigation, 2020 Aug 3;130(8):3987-4005. (IF=14.8)  

8. Jiapei Yuan^#, Jingrui Li^#, Yang Yang, Chang Tan, Yumin Zhu, Long Hu, Yijun Qi^*, Zhi John Lu^*. Stress-responsive regulation of long non-coding RNA polyadenylation in Oryza sativa. The Plant Journal, 2018 Mar;93(5):814-827. (IF=5.726).

9. Jiapei Yuan^#, Ye Zhang^#, Jinsong Dong, Yuzhe Sun, Boon L Lim, Dong Liu^*, Zhi John Lu^*. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016 Aug 18;17:655.

10. Chao Di^#, Jiapei Yuan^#, Yue Wu, Jingrui Li, Huixin Lin, Long Hu, Ting Zhang, Yijun Qi, Mark B Gerstein, Yan Guo, Zhi John Lu^*. Characterization of stress-responsive lncRNA in Arabidopsis Thaliana by integrating expression, epigenetic and structural features. The Plant Journal, 2014 Dec;80(5):848-61. (ESI highly cited paper, in the top 1% of the academic field of Plant & Animal Science). (IF= IF=5.726).