邓敏，研究员，博士生导师，中国医学科学院肿瘤医院放疗科放射生物室主任，分子肿瘤学全国重点实验室研究员，中华医学会肿瘤放射治疗分会生物学组委员。
      院校引进人才，2021年加入中国医学科学院肿瘤医院。2011-2021年在Mayo Clinic从事DNA损失应答相关研究，历任Research fellow，Research Associate和Assistant professor。长期从事DNA损伤应答与肿瘤治疗机制研究，主持国家自然科学基金面上项目、“2030四大慢病”国家科技重大项目子课题等。已在Trends in Cell Biology、Molecular Cell、Nature Communications、Science Advances等期刊发表论文三十余篇，被引2600余次，授权国际专利3项。

长期从事DNA损伤应答（DDR）信号通路及其在肿瘤放化疗和免疫治疗中的作用机制研究。重点关注肿瘤细胞DNA修复、代谢重编程与免疫微环境间的相互调控，系统解析放射抗性与治疗敏感性的分子基础。相关成果发表于Trends in Cell Biology、Molecular Cell、Cancer Research、Science Advances、Nature Communications等国际高影响力期刊，提出多条具有创新性的信号通路模型，为精准放疗及放射免疫联合治疗提供了重要理论依据和潜在干预靶点。

1．Li C^#, Zhao X^#, Li X, Wang C, Huo Z, Xu X, Kang W, Nowsheen S, Aziz K, Sun G, Liu Z*, Lou Z*, Deng M* . Targeting the ATM–TGS1–BRCA1 Axis Overcomes Genotoxic Therapy Resistance in Pancreatic Adenocarcinoma. Cancer Res, 2025 (accepted); 通讯作者; SCI; IF = 16.6 (JCR 2024);

2．Yang Y#, … , Lou Z*, Deng M* . Targeting the ATM-TRMT10A-BRCA1 Axis Confers Synthetic Lethality to PARP Inhibition in Metastatic Castration-Resistant Prostate Cancer. Sci Adv, 2025; 通讯作者; SCI; IF = 12.5 (JCR 2024);

3．Xu Y#, Li C#, … , Lou Z*, Deng M* . STK39-Mediated Amplification of γ-H2AX Promotes Homologous Recombination and Contributes to PARP Inhibitor Resistance. Nucleic Acids Res, 2024; 通讯作者; SCI; IF = 13.1 (JCR 2024);

4．Xu X, Fang Y, Nowsheen S, Li YX, Lou Z*, Deng M* . Regulation of AMPK Activation by Extracellular Matrix Stiffness in Pancreatic Cancer. Genes Dis, 2023; 通讯作者; SCI; IF = 6.9 (JCR 2023);

5．Guo G^#, Gao M^#, Gao X, Zhu B, Huang J, Tu X, Kim W, Zhao F, Zhou Q, Zhu S, Wu Z, Yan Y, Zhang Y, Zeng X, Zhu Q, Yin P, Luo K, Sun J, Deng M*, Lou Z* . Reciprocal Regulation of RIG-I and XRCC4 Connects DNA Repair with RIG-I Immune Signaling. Nat Commun, 2021; 并列通讯; SCI; IF = 17.7 (JCR 2021);

6．Gao M^#, Guo G^#, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M*, Billadeau D*, Lou Z* . DOCK7 Protects Against Replication Stress by Promoting RPA Stability on Chromatin. Nucleic Acids Res, 2021; 并列通讯; SCI; IF = 19.16 (JCR 2021);

7．Deng M*, Hou J, Lou Z* . Bivalent Recognition of Histone Marks by BARD1. Trends Cell Biol, 2021; 第一作者 / 并列通讯; SCI; IF = 21.17 (JCR 2021);

8．Deng M^#, Lin J^#, Nowsheen S, Liu T, Zhao Y, Villalta PW, Sicard D, Tschumperlin DJ, Lee S, Kim J, Lou Z . Extracellular Matrix Stiffness Determines DNA Repair Efficiency and Cellular Sensitivity to Genotoxic Agents. Sci Adv, 2020; 并列一作 / 并列通讯; SCI; IF = 11.7 (JCR 2020);

9．Deng M^#, Yang X^#, Qin B^#, Liu T, Zhang H, Guo W, Lee SB, Kim JJ, Yuan J, Pei H, Wang L, Lou Z* . Deubiquitination and Activation of AMPK by USP10. Mol Cell, 2016; 第一作者; SCI; IF = 14.71 (JCR 2016); 备注：Featured Article

10．Yuan J^#, Luo K^#, Deng M^#, Li Y, Yin P, Gao B, Fang Y, Wu P, Liu T, Lou Z* . HERC2–USP20 Axis Regulates DNA Damage Checkpoint Through Claspin. Nucleic Acids Res, 2014; 并列第一作者; SCI; IF = 9.11 (JCR 2014)